Invention Grant
- Patent Title: Beta-hairpin peptidomimetic with elastase inhibitory activity and aerosol dosage forms thereof
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Application No.: US16305714Application Date: 2017-05-31
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Publication No.: US11235024B2Publication Date: 2022-02-01
- Inventor: Christian Ludin , Manfred Keller , Piet Bruijnzeel , Johann Zimmermann , Philip Barth , Eric Chevalier
- Applicant: POLYPHOR AG
- Applicant Address: CH Allschwil
- Assignee: POLYPHOR AG
- Current Assignee: POLYPHOR AG
- Current Assignee Address: CH Allschwil
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: EP16020210 20160531
- International Application: PCT/EP2017/025157 WO 20170531
- International Announcement: WO2017/207118 WO 20171207
- Main IPC: A61K38/12
- IPC: A61K38/12 ; A61P11/08 ; A61K9/00

Abstract:
The present invention relates to pharmaceutical aerosols comprising a β-hairpin peptidomimetic of formula cyclo(-OctG-Glu-Thr-Ala-Ser-Ile-Pro-Pro-Gln-Lys-Tyr-DPro-Pro-), or a pharmaceutically acceptable salt thereof, having inhibitory activity against human neutrophil elastase. It further relates to solid or liquid pharmaceutical compositions and kits for preparing and administering such aerosols. The invention can be used for the prevention, management or treatment of pulmonary diseases, such as alpha-1 antitrypsin deficiency (AATD), cystic fibrosis (CF), non-cystic fibrosis bronchiactasis (NCFB), or chronic obstructive pulmonary disease (COPD), or infections, or diseases, or conditions of the lungs, being mediated by or resulting from human neutrophil elastase activity. Thus, the invention further relates to a pharmaceutical composition or a pharmaceutical aerosol comprising the active compound cyclo(-OctG-Glu-Thr-Ala-Ser-Ile-Pro-Pro-Gln-Lys-Tyr-DPro-Pro-), or any pharmaceutically acceptable salt thereof, for use in a method for the prevention, management or treatment of diseases or conditions of the lungs being mediated by or resulting from human neutrophil elastase activity in a subject.
Public/Granted literature
- US20200230203A1 BETA-HAIRPIN PEPTIDOMIMETIC WITH ELASTASE INHIBITORY ACTIVITY AND AEROSOL DOSAGE FORMS THEREOF Public/Granted day:2020-07-23
Information query
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