Technologies for secure native code invocation include a computing device having an operating system and a firmware environment. The operating system executes a firmware method in an operating system context using a virtual machine. In response to invoking the firmware method, the operating system invokes a callback to a bridge driver in the operating system context. In response to the callback, the bridge driver invokes a firmware runtime service in the operating system context. The firmware environment executes a native code handler in the operating system context in response to invoking the firmware runtime service. The native code handler may be executed in a de-privileged container. The firmware method may process results data stored in a firmware mailbox by the native code handler, which may include accessing a hardware resource using a firmware operation region.