Methods and systems for monitoring the integrity of a graphics processing unit (GPU) are provided. The method comprises the steps of determining a known-good result associated with an operation of the GPU, and generating a test image comprising a test subject using the operation of the GPU, such that the test subject is associated with the known-good result. The test image is written to video memory, and the known-good result is written to system memory. Subsequently, the test subject from the test image is transferred from video memory to system memory. The test subject in the system memory is compared with the known-good result in system memory. If the test subject does not match the known-good result, then a conclusion is drawn that the integrity of the GPU has been compromised.