Logically-defined pixel interfaces and video frame transfer techniques are provided herein. In one example, a method includes receiving a video frame representing source pixels, where the video frame comprises logical pixels that each represent more than one source pixel according to a selected sizing and metadata that indicates the selected sizing for the logical pixels and indicators of which pixels included in the video frame comprise the logical pixels. The method also includes interpreting the metadata for the logical pixels to map each of the logical pixels across more than one output pixel according to the selected sizing and the indicators included in the metadata.