The presented technology is directed to devices, systems, and their methods of use for evaluating and optimizing the effectiveness of digital advertisements to increase sales such as in a digital ad-buying platform. In particular, the presented platform is configured for determining incremental lift of a product due to an advertisement and/or a promotion that is distributed online. Presented herein, therefore, are devices, systems, and methods of monitoring, measuring, and/or optimizing lift of an advertising campaign, such as a real-time, digital ad buying campaign implemented by a suitably configured advertising platform.