A screw-driven control system includes a driving mechanism fixed in a cross beam, a guide locking piece and a limiting mechanism. The driving mechanism includes a screw rod and a motor driven nut assembly having a transmission frame, a nut sleeved in the screw rod, and a follow-up member fixed in the nut; the nut is mounted in the transmission frame, and the transmission frame is connected with a controlled object; the screw rod drives the nut assembly to reciprocate axially along the screw rod.