Invention Grant
- Patent Title: Ligands of the mu, kappa, and delta opioid receptors
-
Application No.: US16763522Application Date: 2018-11-14
-
Publication No.: US11213518B2Publication Date: 2022-01-04
- Inventor: Evan N. Feinberg , Vijay S. Pande , Susruta Majumdar , Gavril Pasternak
- Applicant: The Board of Trustees of the Leland Stanford Junior University , Memorial Sloan-Kettering Cancer Center
- Applicant Address: US CA Stanford; US NY New York
- Assignee: The Board of Trustees of the Leland Stanford Junior University,Memorial Sloan-Kettering Cancer Center
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University,Memorial Sloan-Kettering Cancer Center
- Current Assignee Address: US CA Stanford; US NY New York
- Agency: Bozicevic, Field & Francis LLP
- Agent Jenny L. Buchbinder
- International Application: PCT/US2018/061129 WO 20181114
- International Announcement: WO2019/099573 WO 20190523
- Main IPC: A61K31/4453
- IPC: A61K31/4453 ; A61K31/415 ; A61K9/00
Abstract:
Ligands of the mu, kappa, and delta opioid receptors and methods of using them are disclosed. In particular, the invention relates to the discovery of new opioid receptor ligands based on molecular dynamics simulations of conformational states of the μ opioid receptor and the use of the identified opioid receptor ligands as analgesics, anti-diarrheal agents, and overdose reversal agents.
Public/Granted literature
- US20200345715A1 Ligands of the Mu, Kappa, and Delta Opioid Receptors Public/Granted day:2020-11-05
Information query
IPC分类:
