A device for refilling vape solution has a controller, a plurality of raw material containers, a mixer, a plurality of input controlling valves, and an output controlling valve. The plurality of raw material containers are respectively used for storing a kind of raw material. Each of the input controlling valves is used for connecting the mixer and one of the raw material containers and controlled by the controller to be opened or closed so as to selectively allow the raw material to be injected into the mixer. The output controlling valve is connected to the mixer and controlled by the controller to be opened or closed so as to output a product solution. The mixer is controlled by the controller to mix the raw materials therein so as to generate the product solution.