Invention Grant
- Patent Title: 2′-fluoro-6′-methylene carbocyclic nucleosides and methods of treating viral infections
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Application No.: US16696708Application Date: 2019-11-26
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Publication No.: US11082386B2Publication Date: 2021-08-03
- Inventor: Chung K. Chu , Jianing Wang
- Applicant: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
- Applicant Address: US GA Athens
- Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
- Current Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
- Current Assignee Address: US GA Athens
- Agent Henry D. Coleman; R. Neil Sudol
- Main IPC: A61K31/52
- IPC: A61K31/52 ; C07D473/34 ; C07D473/18 ; A61K31/522 ; A61P31/20 ; H04L12/58 ; A61K45/06 ; A61K31/675
Abstract:
The present invention relates to 2′-Fluoro-6′-methylene carbocyclic nucleosides, pharmaceutical compositions containing these nucleosides and their use in the treatment or prophylaxis of a number of viral infections and secondary disease states and conditions thereof, especially including Hepatitis B virus (HBV) and secondary disease states and conditions thereof (cirrhosis and liver cancer), Heptatitis C virus (HCV), Herpes Simplex virus I and II (HSV-1 and HSV-2), cytomegalovirus (CMV), Varicella-Zoster Virus (VZV) and Epstein Barr virus (EBV) and secondary cancers which occur thereof (lymphoma, nasopharyngeal cancer, including drug resistant (especially including lamivudine and/or adefovir resistant) and other mutant forms of these viruses, especially HBV.
Public/Granted literature
- US20200220830A1 2'-Fluoro-6'-Methylene Carbocyclic Nucleosides and Methods of Treating Viral Infections Public/Granted day:2020-07-09
Information query
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