Invention Grant
- Patent Title: Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
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Application No.: US16286075Application Date: 2019-02-26
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Publication No.: US11078485B2Publication Date: 2021-08-03
- Inventor: Charles Allerson , Balkrishen Bhat , Anne B. Eldrup , Muthiah Manoharan , Richard H. Griffey , Brenda F. Baker , Eric E. Swayze
- Applicant: Ionis Pharmaceuticals, Inc.
- Applicant Address: US CA Carlsbad
- Assignee: Ionis Pharmaceuticals, Inc.
- Current Assignee: Ionis Pharmaceuticals, Inc.
- Current Assignee Address: US CA Carlsbad
- Agency: McNeill Baur PLLC
- Main IPC: C12N15/113
- IPC: C12N15/113 ; C07H21/00 ; C07H21/04 ; C12N15/11 ; A61K48/00 ; C07H21/02
Abstract:
The present invention provides compositions comprising at least one oligomeric compound comprising an alternating motif and further include a region that is complementary to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In preferred embodiments the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression.
Public/Granted literature
- US20200017855A1 COMPOSITIONS COMPRISING ALTERNATING 2'-MODIFIED NUCLEOSIDES FOR USE IN GENE MODULATION Public/Granted day:2020-01-16
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