New peripheral device cases and methods of use are provided. In some embodiments, specialized hardware for acquiring personal health data is provided within a smartphone case. In some such embodiments, a case with squeezable sections is provided, configured to monitor pressure applied by a user and record a user's grip strength. In some embodiments, optical sensors are provided which monitor and assess a user's behavior while extrapolating user statuses based on behavior. For example, a new form of transparent pixel array is provided over the screen of a smartphone held within a case, and records both visual data and user input related to the screen, while permitting normal actuation of the smartphone screen through the transparent pixel array. In some embodiments, data is secured and managed within separate computer hardware within a case, and shared with a smartphone held within it, and/or with a network, upon obtaining user consent.