Systems and methods, as well as devices, are described for clinical resource generation. CCDA documents that include clinical information and observations are utilized to generate FHIR model instances that are specific to the CCDA documents. Path definitions are assigned for each information-value pair the CCDA documents that define mappings between the information-value pairs and objects of FHIR model instances. Objects for the instance models are created, and values are provided to the objects representative of the information-value pairs. Groups of objects are provided in FHIR resource bundles that are stored in a database which may be queried against to provide specific FHIR resources upon request. Requests for clinical information may be used to trigger the generation of the FHIR resource bundles.