A system and a method for analyzing and evaluating genome data in the course of personalized medicine. In-memory technology is provided for processing of genome data and its real-time analysis as a holistic process in the course of personalized medicine. The cloud application helps physicians and researchers to identify the genetic roots for certain tumor types in the treatment of diseases correlating to genomic variants or mutations, such as cancer diseases. The system combines the latest international research results with patient-specific genomic data while eliminating the need for long-lasting manual searches of all dispositions in distributed international research and literature data sources.