Provided are a cell image evaluation device, method, and program which are capable of performing more accurate and high reliable evaluation even though a captured image of each part to be observed within a container is an image of which contrast is low due to influence of meniscus. The cell image evaluation device includes a region determination unit that determines whether a captured image obtained by capturing an inside of a container that contains a cell is an image obtained by capturing a meniscus region within the container or an image obtained by capturing a non-meniscus region within the container and an image evaluation unit that evaluates a state of the cell included in the captured image. The image evaluation unit evaluates the image of the meniscus region and the image of the non-meniscus region by different evaluation methods.