A method of controlling a photoacoustic imaging diagnosis apparatus includes irradiating to an object an optical signal having a wavelength corresponding to an optical energy absorption wavelength of a contrast medium that is injected to the object; receiving a photoacoustic signal generated from the object in response to the optical signal; generating scan information representing an intensity of the photoacoustic signal based on the photoacoustic signal; determining a damage degree of the object by using a variation in the intensity of the photoacoustic signal during a preset time period included in the scan information; and displaying the damage degree of the object.