A multi-objective optimization method for groundwater pollution monitoring network, which mainly includes four steps: groundwater numerical value simulation, groundwater vulnerability assessment, the establishment of the monitoring network optimization model, and the solving of the optimization model. The core of the method is to establish a multi-objective optimization model aimed at establishing the least monitoring wells, monitoring the maximum pollutant concentration, and monitoring the maximum regional vulnerability value. Solving the optimization model by the algorithm and considering the relationship between the quality error and the number of monitoring wells comprehensively to determine the well number and location of the monitoring network.