A method of determining a modulation and coding scheme includes: acquiring UCI transmitted by UE, the UCI including at least a CQI index; determining whether the CQI index belongs to a CQI compression index representing at least two modulation and coding schemes; when the CQI index belongs to the CQI compression index, determining a modulation and coding scheme represented by the CQI compression index according to preset CQI compression index indication information; and determining modulation and coding configuration information for the UE according to the modulation and coding scheme, and transmitting the modulation and coding configuration information to the UE. By adopting the method of determining the modulation and coding scheme, a higher-order modulation and coding scheme may be configured for the UE based on a relevant CQI index to reduce calculation amount during analyzing the modulation and coding scheme.