In various embodiments, a drainage device includes an inner lumen configured for draining fluid from a target site and one or more outer lumens for transmitting dilution fluid to the inner lumen. According to one embodiment, the drainage device includes one or more eyelets and/or a distal opening through which the fluid from the target site enters the inner lumen. In one or more embodiments, the dilution fluid is transmitted to the inner lumen through one or more ports that may output the dilution fluid directly into the inner lumen or into the eyelet. According to one embodiment, as the fluid from the target site flows through the drainage device, the dilution fluid reduces clotting processes such that formation of blockages within the inner lumen is prevented or at least reduced. In some embodiments, the dilution fluid is substituted with, or provided in addition to, pharmaceutical solutions or other infusions.