Invention Grant
- Patent Title: Fosfomycin formulation for parenteral administration
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Application No.: US16869646Application Date: 2020-05-08
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Publication No.: US10993951B2Publication Date: 2021-05-04
- Inventor: Apostolos Georgopoulos , Albert Schifer , Wolfgang Rous
- Applicant: Apostolos Georgopoulos , Albert Schifer , Wolfgang Rous
- Applicant Address: AT Vienna; AT Vienna; AT Vienna
- Assignee: Apostolos Georgopoulos,Albert Schifer,Wolfgang Rous
- Current Assignee: Apostolos Georgopoulos,Albert Schifer,Wolfgang Rous
- Current Assignee Address: AT Vienna; AT Vienna; AT Vienna
- Agency: Chalker Flores, LLP
- Agent Edwin S. Flores; Daniel J. Chalker
- Priority: EP16160698 20160316
- Main IPC: A61K31/665
- IPC: A61K31/665 ; A61K9/08 ; A61K9/00 ; A61K47/12

Abstract:
The field of the present invention is that of fosfomycin formulations for parenteral administration, in particular for intravenous administration. Formulations of the prior art provide fosfomycin as a powder to be diluted directly prior to the administration. The aim of the invention is to provide a fosfomycin formulation for parenteral administration which is easier to produce and administer or which lowers the risk of puncture injuries for healthcare professionals and the health risks for the patients (for example due to contamination or incorrect dosages) by preventing additional processing steps. During the course of the invention, it was surprisingly shown that fosfomycin is much more stable in an aqueous solution than what is commonly assumed. The invention therefore provides a closed container which contains an aqueous solution for parenteral administration, wherein at least one pharmaceutically acceptable salt of fosfomycin, in particular fosfomycin disodium salt, and a pharmaceutically acceptable acid, in particular succinic acid, are dissolved in the solution. Preferred containers are breakable ampoules made of plastic or glass, puncturable vials, infusion bags, or syringes ready for injection.
Public/Granted literature
- US20200261478A1 Fosfomycin Formulation for Parenteral Administration Public/Granted day:2020-08-20
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