Systems, devices, and techniques described herein are directed to network based personal number blocking. In particular, the systems, devices, and techniques can be implemented in networks including user equipment (UE) associated with native numbers and alias numbers, and can include blocking native numbers or alias numbers. Further, users can access a user profile or an application via a UE to assign personal number blocking (PNB) preferences to the various native numbers and alias numbers. Indications of such PNB can be transmitted from a UE to a network device to update a user profile in a central repository or database. If a user activates another UE or otherwise associates additional native numbers or alias numbers, the PNB can be seamlessly applied to the new device or numbers.