The embodiment of the disclosure discloses a method, a device and a mobile terminal for preventing a false-touch on a touch screen. The method may include comparing an area of a touch area corresponding to a touch event with a preset area threshold; determining whether the touch area overlaps with a touch button area, when the area of the touch area is smaller than the preset area threshold; marking touch points inside the touch button area as invalid touch points, shielding location coordinates of the invalid touch points and location coordinates of the touch points inside a preset area, reporting location coordinates of remaining touch points, when the touch area corresponding to the touch event partially overlaps with the touch button area; and reporting location coordinates corresponding to the touch event, when the touch area corresponding to the touch event does not overlap with the touch button area.