Invention Grant
- Patent Title: Use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases
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Application No.: US15934735Application Date: 2018-03-23
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Publication No.: US10967038B2Publication Date: 2021-04-06
- Inventor: Jean-Marc Combette , Catherine Deloche , Claire Abadie
- Applicant: Xigen Inflammation Ltd.
- Applicant Address: CY Limassol
- Assignee: Xigen Inflammation Ltd.
- Current Assignee: Xigen Inflammation Ltd.
- Current Assignee Address: CY Limassol
- Agency: Harness Dickey & Pierce P.L.C.
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K14/00 ; A61K38/17

Abstract:
The present invention refers to the use of protein kinase inhibitors and more specifically to the use of inhibitors of the protein kinase c-Jun amino terminal kinase, JNK inhibitor (poly-)peptides, chimeric peptides, or of nucleic acids encoding same as well as pharmaceutical compositions containing same, for the treatment of non-chronic or chronic inflammatory eye diseases, such as inflammatory diseases of the blephara, conjunctiva, cornea, sclera, the vitreous body, uvea, ciliary body, choroid, orbital bone, lacrimal gland, or iris, in particular wherein the inflammatory disease is selected from hordeolum, chalazion, conjunktivitis, keratitis, scieritis, episcleritis, endophthalmitis, panophtalmitis, irititis, uveitis, cyclitis, chorioiditis, orbital phlegmon, and myositis of the eye muscle etc.
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