Techniques regarding autonomously updating a participation status of an entity with regards to a clinical trial are provided. For example, one or more embodiments described herein can comprise a system, which can comprise a memory that can store computer executable components. The system can also comprise a processor, operably coupled to the memory, and that can execute the computer executable components stored in the memory. The computer executable components can comprise status component that can update a participation status of an entity regarding a clinical trial based on a trust disposition value. The trust disposition value can be determined using machine learning technology and can be indicative of an expected enrichment contribution associated with the participation status.