Invention Grant
- Patent Title: Expression of proteins in gram-negative bacteria wherein the ratio of periplasmic volume to cytoplasmic volume is between 0.5:1 and 10:1
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Application No.: US16088797Application Date: 2017-03-29
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Publication No.: US10941406B2Publication Date: 2021-03-09
- Inventor: Nikolay Ouzounov
- Applicant: Geltor, Inc.
- Applicant Address: US CA San Leandro
- Assignee: Geltor, Inc.
- Current Assignee: Geltor, Inc.
- Current Assignee Address: US CA San Leandro
- Agency: Wilson Sonsini Goodrich & Rosati
- International Application: PCT/US2017/024857 WO 20170329
- International Announcement: WO2017/172994 WO 20171005
- Main IPC: C12P21/02
- IPC: C12P21/02 ; C12N15/70 ; C07K14/78 ; C12N1/20 ; C12N15/67 ; C07K16/00
Abstract:
Provided are modified Gram-negative bacteria having an increased periplasmic volume. Also provided are methods of expressing exogenous genes in the bacteria and targeting protein production to the periplasmic space.
Public/Granted literature
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