Invention Grant
- Patent Title: Methods, systems, and apparatuses for tissue ablation using pulse shape designs
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Application No.: US15570914Application Date: 2015-05-13
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Publication No.: US10939949B2Publication Date: 2021-03-09
- Inventor: Boris Rubinsky , Paul Mikus , Liel Rubinsky , Michael Klaus Stehling , Enric Günther
- Applicant: INTER SCIENCE GMBH , RM2 TECHNOLOGY LLC
- Applicant Address: CH Gisikon; US CA Rancho Mission Viejo
- Assignee: INTER SCIENCE GMBH,RM2 TECHNOLOGY LLC
- Current Assignee: INTER SCIENCE GMBH,RM2 TECHNOLOGY LLC
- Current Assignee Address: CH Gisikon; US CA Rancho Mission Viejo
- Agency: Dorsey & Whitney LLP
- International Application: PCT/US2015/030628 WO 20150513
- International Announcement: WO2016/178697 WO 20161110
- Main IPC: A61B18/12
- IPC: A61B18/12 ; A61B18/14 ; A61N1/20 ; A61B18/00 ; A61B5/145 ; A61N1/32

Abstract:
Example methods and apparatuses are disclosed for providing tissue ablation through electrolysis, electroporation, or a combination thereof. A way to deliver the combination through a pulse that has an element of gradual decay and can thereby reduce both muscle contraction and electric breakdown discharge at the electrodes is disclosed. The apparatus disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through a treatment site to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site.
Public/Granted literature
- US20180193082A1 METHODS, SYSTEMS, AND APPARATUSES FOR TISSUE ABLATION USING PULSE SHAPE DESIGNS Public/Granted day:2018-07-12
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