An information handling system audio system includes a library of noise reduction filters associated with cooling fan speeds to isolate out cooling fan noise. Changed cooling fan settings communicated to the audio system trigger application of a library noise reduction filter for the selected cooling fan setting to isolate out cooling fan noise while an adaptive filter defines a noise reduction filter from recorded sounds. The library noise reduction filter reduces cooling fan noises during the time used to determine the adaptive noise reduction filter. In one embodiment, changes in cooling fan settings prioritize definition of noise reduction filters by the adaptive filter.