A method of multi-sensor alignment includes mechanically moving at least one sensor in a plurality of sensors to boresight and focus the plurality of sensors with one another so a respective optical center of each of the plurality of sensors is aligned and focused. The method includes collecting calibration images of a target wherein each sensor of the plurality of sensors collects at least one image of the target, and analytically comparing the images with one another to produce a look up table (LUT) of optical distortion and spatial registration for registration of image data from the plurality of sensors. The method includes saving the LUT in sensor memory for use in registering live images from the plurality of sensors.