Invention Grant
- Patent Title: Heteroaromatic modulators of the retinoid-related orphan receptor gamma
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Application No.: US16874961Application Date: 2020-05-15
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Publication No.: US10934282B2Publication Date: 2021-03-02
- Inventor: Alan Stuart Jessiman , Patrick Stephen Johnson , Kristoffer Maansson , Morten Dahl Sørensen
- Applicant: LEO PHARMA A/S
- Applicant Address: DK Ballerup
- Assignee: LEO PHARMA A/S
- Current Assignee: LEO PHARMA A/S
- Current Assignee Address: DK Ballerup
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- Priority: EP16020268 20160713
- Main IPC: C07D413/14
- IPC: C07D413/14 ; C07D413/12 ; C07D417/14 ; C07D241/04

Abstract:
The present invention relates to a compound according to general formula (I) wherein X represents N or CH; R1 is —CN, (C1-C6)alkyl, (C3-C7)cycloalkyl, (3-7 membered)heterocycloalkyl, (5-6 membered)heteroaryl, (C3-C7)cycloalkyl(C1-C4)alkyl, (3-7 membered)heterocycloalkyl-(C1-C4)alkyl or (5-6 membered)heteroaryl-(C1-C4)alkyl; R2 is halogen, cyano, (C1-C4)alkyl or (C3-C7)cycloalkyl; R3 is halogen, cyano, (C1-C4)alkyl, (C1-C4)haloalkyl or (C3-C7)cycloalkyl; R4 is (C1-C4)alkyl or (C1-C4)haloalkyl; R5 is (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)alkyl-(C3-C7)cycloalkyl, (C3-C7)cycloalkyl-(C1-C6)alkyl, (3-7 membered)heterocycloalkyl, phenyl, (5-6 membered)heteroaryl or —ORa. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds and to intermediates for preparation of said compounds.
Public/Granted literature
- US20200291010A1 HETEROAROMATIC MDOULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA Public/Granted day:2020-09-17
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