Invention Grant
- Patent Title: Compositions and methods for reducing the risk of radiocontrast-induced nephropathy
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Application No.: US16393422Application Date: 2019-04-24
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Publication No.: US10933145B2Publication Date: 2021-03-02
- Inventor: Sohail Husain
- Applicant: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
- Applicant Address: US PA Pittsburgh
- Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
- Current Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
- Current Assignee Address: US PA Pittsburgh
- Agency: Baker Botts L.L.P.
- Main IPC: A61K49/04
- IPC: A61K49/04 ; A61P13/12 ; A61K38/13 ; A61K31/436
Abstract:
The present invention relates to compositions and methods for reducing the risk and/or extent of radiocontrast-induced nephropathy (“RIN”) for kidney-imaging procedures that employ a radiocontrast medium. It is based, at least in part, on the discovery that, in a renal tubular cell line, radiocontrast induced inflammatory upregulation and cell injury could be reduced by calcineurin inhibitors FK506 and cyclosporine.
Public/Granted literature
- US20190247521A1 COMPOSITIONS AND METHODS FOR REDUCING THE RISK OF RADIOCONTRAST-INDUCED NEPHROPATHY Public/Granted day:2019-08-15
Information query
