Invention Grant
- Patent Title: Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
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Application No.: US16654844Application Date: 2019-10-16
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Publication No.: US10933054B2Publication Date: 2021-03-02
- Inventor: Yaron R. Hadari , Luca Carta , Michael Schmertzler , Theresa M. Williams , Charles H. Reynolds , Rebecca Hutcheson
- Applicant: Shy Therapeutics LLC
- Applicant Address: US NY Harrison
- Assignee: Shy Therapeutics LLC
- Current Assignee: Shy Therapeutics LLC
- Current Assignee Address: US NY Harrison
- Agency: Jones Day
- Main IPC: C07D495/04
- IPC: C07D495/04 ; A61K31/4365 ; A61P29/00 ; A61P35/00 ; A61P25/28 ; A61K31/505 ; C12N15/10
Abstract:
Provided herein are methods and compositions for treating cancers, inflammatory diseases, rasopathies, and fibrotic disease involving aberrant Ras superfamily signaling through the binding of compounds to the GTP binding domain of Ras superfamily proteins including, in certain cases, K-Ras and mutants thereof, and a novel method for assaying such compositions.
Public/Granted literature
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