Invention Grant
![1,3-diazo-4-oxa-[3.3.1]-bicyclic derivatives, process for their manufacture and their use as a medicament, in particular for treating diabetes](/docs/US/2021-02-09/US10913751B2/abs.jpg.600x600.jpg)
- Patent Title: 1,3-diazo-4-oxa-[3.3.1]-bicyclic derivatives, process for their manufacture and their use as a medicament, in particular for treating diabetes
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Application No.: US16616119Application Date: 2018-05-30
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Publication No.: US10913751B2Publication Date: 2021-02-09
- Inventor: Francesco Berti , Mauro Pineschi , Andrea Menichetti
- Applicant: UNIVERSITA' DI PISA
- Applicant Address: IT Pisa
- Assignee: UNIVERSITA' DI PISA
- Current Assignee: UNIVERSITA' DI PISA
- Current Assignee Address: IT Pisa
- Agency: Silvia Salvadori, P.C.
- Agent Silvia Salvadori
- Priority: IT102017000059292 20170531
- International Application: PCT/IB2018/053834 WO 20180530
- International Announcement: WO2018/220542 WO 20181206
- Main IPC: C07D498/08
- IPC: C07D498/08 ; A61P3/10
![1,3-diazo-4-oxa-[3.3.1]-bicyclic derivatives, process for their manufacture and their use as a medicament, in particular for treating diabetes](/abs-image/US/2021/02/09/US10913751B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to compounds having structural formula (I) wherein R1 and R2 are defined as set forth in the description. The invention also relates to a process for the manufacture of the above compounds of formula (I), wherein a 4a,7,8,8a-tetrahydropyrido[4,3-e]-1,4,2-dioxazine reacts with a hydride selected from the group consisting of: lithium triethylborohydride (LiBHEt3), sodium triethylborohydride (NaBHEt3), and lithium tetrahydroaluminate (LiAlH4), in the presence of tetrahydrofuran. Furthermore, the invention is aimed at the above compounds of formula (I), or pharmaceutically acceptable salts thereof, for use in medicine, preferably in the treatment of the diabetes and pathologies or conditions correlated thereto.
Public/Granted literature
Information query
