A handgrip structure of a hand tool includes a handgrip body, a foldable cover and an installation set; a chamber is formed in the handgrip body, and an opening is formed at one side of the chamber; the foldable cover has one end pivoted with the handgrip body and served to cover the opening, wherein a tool accommodation room is formed between the foldable cover and the chamber of the handgrip body; and the installation set is disposed on the handgrip body and arranged corresponding to another end of the foldable cover. Accordingly, a large amount of tool heads can be stably fastened and the tool heads can be easily taken out and stored, so that features of easy in operation and convenient in storage are achieved.