A pipette calibration and volume offset mechanism. The calibration and volume offset mechanism is provided to facilitate user selectable calibration or volume offset operations of a pipette to which the calibration and volume offset mechanism is installed, through axial displacement of a threaded element that effectively moves the home position of the pipette. An offset counter of the calibration and volume offset mechanism is rotationally coupled to the threaded element during a volume offset operation to indicate offset magnitude, but decoupled from threaded element during a calibration or recalibration operation.