A chip on film package structure including a flexible film and a chip is provided. The flexible film includes a main body and a first wing body. The main body includes a main bonding portion configured to be bonded to a first substrate. The first wing body includes a first extending part and a first bent part. The first extending part is extended from a side of the main body. The first bent part is configured to be bent to a second substrate and having a first wing bonding portion. The first wing bonding portion is configured to be bonded to the second substrate. The first substrate and the second substrate are stacked on top of each other. The chip mounted on and electrically connected to the main body. A display device is also provided.