An anti-fuse memory cell may include a substrate including first and second conductivity regions and an isolation region at least partially within the substrate, a program gate over the substrate, a program gate oxide layer over the isolation region and between the program gate and the substrate, a first channel region arranged laterally between the first conductivity region and the isolation region, a second channel region arranged laterally between the second conductivity region and the isolation region, a first select gate arranged over the substrate and over the first channel region and a second select gate arranged over the substrate and over the second channel region. The program gate oxide layer may be configured to break down to allow conduction between the program gate and at least one of the channel regions upon providing a program voltage difference between the program gate and at least one of the channel regions.