A system and method for mobile application virtualization. The system includes a server based architecture for mobile application virtualization. The architecture includes a single operating system instantiation resident on a server computer system. The single operating system includes a session management module and a plurality of service modules. The architecture further includes a plurality of user sessions each session comprising a plurality of applications and a unique session ID. The plurality of user sessions are operable to call services of the single operating system. The architecture further includes a plurality of virtual device sets each set comprising a unique session ID and associated with a respective user session of the plurality of user sessions. Upon receiving an application programming interface (API) call from an application of a first user session to a first service module of the plurality of service modules, the single operating system is operable to map the API call to a first set of virtual devices that shares a same session ID as a session ID of the first user session for fulfillment of the API call by the first service module.