Disclosed embodiments relate to cloud scaling with non-blocking, non-spinning cross-domain event synchronization and data communication. In an example, a processor includes a memory to store multiple virtual hardware thread (VHTR) descriptors, each including an architectural state, a monitored address range, a priority, and an execution state, fetch circuitry to fetch instructions associated with a plurality of the multiple VNFs, decode circuitry to decode the fetched instructions, scheduling circuitry to allocate and pin a VHTR to each of the plurality of VNFs, schedule execution of a VHTR on each of a plurality of cores, set the execution state of the scheduled VHTR; and in response to a monitor instruction received from a given VHTR, pause the given VHTR and switch in another VHTR to use the core previously used by the given VHTR, and, upon detecting a store to the monitored address range, trigger execution of the given VHTR.