Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a network controller may determine a first set of spreading sequences and a second set of spreading sequences for non-orthogonal multiple access (NOMA) communication, wherein the first set of spreading sequences is different than the second set of spreading sequences; and configure a first cell to use the first set of spreading sequences and a second cell to use the second set of spreading sequences; or configure the first set of spreading sequences to be used for first user equipment associated with a cell center of the first cell and the second set of spreading sequences to be used for second user equipment associated with a cell edge of the first cell or the second cell. Numerous other aspects are provided.