The present disclosure relates to, inter alia, systems and methods for measuring contact-line mobility of a liquid on a solid substrate. The system includes a motion-generation component, a motion-measurement component, and a computer component. The motion-generation component can include an actuator and a controller, the actuator being adapted to mount a solid substrate and effective to impart periodic forcing to the solid substrate when a test droplet of the liquid is deposited thereon, and the controller being adapted to tune frequency and amplitude of the forcing to induce measurable contact-line displacement of the test droplet on the solid substrate. The motion-measurement component includes an image acquisition device adapted for capturing images of the test droplet. The image acquisition device has requisite spatial and temporal resolution to enable acquisition of image data of the test droplet, the image data including contact-line displacement, contact-line speed, and contact angle at or near contact-line.