The present disclosure provides an antenna system for optimizing isolation and a mobile terminal. The system defines clearance slots in an electromagnetic conductor and between antenna feed points for optimizing isolation between antenna units, and comprises clearance areas disposed on both sides of the electromagnetic conductor having the clearance slots of the circuit board for arranging the antenna feed points. Through the present disclosure, it is possible to increase isolation between the diversity antenna and other antenna in a limited space, avoid the coupling effect between the antennas, and alleviate the problem present in traditional multiple-input multiple-output antennas limited by the size of the terminal device.