Disclosed herein are system, apparatus, article of manufacture, method, and/or computer program product embodiments for real-time asynchronous multitenant gateway security with respect to one or more client devices. An embodiment operates by receiving an event and determining that event content information includes at least a portion of service transaction information and the at least portion of the service transaction information is registered. The embodiment may further operate by determining that the event is a security event based on event type information. The embodiment may then determine whether at least a portion of an external content response has been transmitted to the client device and that a validated connection associated with the service transaction information has not yet been disconnected. Based on those determinations, the embodiment may then interrupt the reverse proxy component to invalidate the external content response and disconnect the validated connection.