Invention Grant
- Patent Title: Transformed fungus having enhanced ergothioneine productivity and method for producing ergothioneine
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Application No.: US15533215Application Date: 2015-12-25
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Publication No.: US10760107B2Publication Date: 2020-09-01
- Inventor: Seiichi Hara , Keiko Kurosawa , Keiichi Ichikawa
- Applicant: KIKKOMAN CORPORATION
- Applicant Address: JP Noda-Shi
- Assignee: KIKKOMAN CORPORATION
- Current Assignee: KIKKOMAN CORPORATION
- Current Assignee Address: JP Noda-Shi
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@377adf09 com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@3711d089
- International Application: PCT/JP2015/086301 WO 20151225
- International Announcement: WO2016/121285 WO 20160804
- Main IPC: C12N9/10
- IPC: C12N9/10 ; C12N9/14 ; C12P13/04 ; C12N15/09 ; C12R1/665 ; C12R1/685 ; C12R1/69 ; C12R1/66

Abstract:
The purpose of the present invention is to provide an organism having an ergothioneine productivity that is capable of easily producing ergothioneine within a short period of time at a high yield, as compared with a conventional technology, and, therefore, enables ergothioneine production on an industrial scale. This purpose can be achieved by a transformed fungus into which a gene encoding enzyme (1) or genes encoding enzymes (1) and (2) have been inserted and in which the inserted gene(s) are overexpressed. (1) an enzyme catalyzing a reaction of synthesizing hercynyl cysteine sulfoxide from histidine and cysteine in the presence of S-adenosyl methionine, iron (II) and oxygen. (2) An enzyme catalyzing a reaction of synthesizing ergothioneine from hercynyl cysteine sulfoxide using pyridoxal 5′-phosphate as a coenzyme.
Public/Granted literature
- US10711290B2 Transformed fungus having enhanced ergothioneine productivity and method for producing ergothioneine Public/Granted day:2020-07-14
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