Invention Grant
- Patent Title: α-amylase-binding nucleic acid molecule and use thereof
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Application No.: US15775797Application Date: 2016-09-12
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Publication No.: US10760084B2Publication Date: 2020-09-01
- Inventor: Hirotaka Minagawa , Katsunori Horii , Jou Akitomi , Naoto Kaneko , Ikuo Shiratori , Iwao Waga , Masayasu Kuwahara
- Applicant: NEC Solution Innovators, Ltd. , Gunma University
- Applicant Address: JP Tokyo JP Gunma
- Assignee: NEC Solution Innovators, Ltd.,Gunma University
- Current Assignee: NEC Solution Innovators, Ltd.,Gunma University
- Current Assignee Address: JP Tokyo JP Gunma
- Agency: Wilmer Cutler Pickering Hale and Dorr LLP
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@2d0bdc5a
- International Application: PCT/JP2016/076741 WO 20160912
- International Announcement: WO2017/081926 WO 20170518
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12N15/115 ; C12Q1/40 ; C12Q1/68 ; G01N33/53 ; C12N15/10
Abstract:
The present invention provides a novel nucleic acid molecule that can be used for detection of α-amylase. The α-amylase-binding nucleic acid molecule of the present invention is characterized in that it binds to α-amylase with a dissociation constant of 17 nM or less, and preferably includes a polynucleotide consisting of any of base sequences of SEQ ID NOs: 1 to 22, for example. According to the nucleic acid molecule of the present invention, it is possible to detect α-amylase in saliva.
Public/Granted literature
- US20180327746A1 Alpha-AMYLASE-BINDING NUCLEIC ACID MOLECULE AND USE THEREOF Public/Granted day:2018-11-15
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