RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci

Invention Grant

US10760064B2 RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci 有权

Patent Title: RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
Application No.: US14211117

Application Date: 2014-03-14
Publication No.: US10760064B2

Publication Date: 2020-09-01
Inventor: J. Keith Joung , Morgan Maeder
Applicant: The General Hospital Corporation
Applicant Address: US MA Boston
Assignee: The General Hospital Corporation
Current Assignee: The General Hospital Corporation
Current Assignee Address: US MA Boston
Agency: Fish & Richardson P.C.
Main IPC: C12N15/85
IPC: C12N15/85 ; C12N15/11 ; C12N15/31 ; C12N15/62 ; C12N15/52 ; C12N9/22 ; C07K14/315 ; C07K14/47 ; C12N15/63 ; C12N15/113

Abstract:

Methods and constructs for RNA-guided targeting of transcriptional activators to specific genomic loci.

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IPC分类:

C	化学；冶金
C12	生物化学；啤酒；烈性酒；果汁酒；醋；微生物学；酶学；突变或遗传工程
C12N	微生物或酶；其组合物；繁殖、保藏或维持微生物；变异或遗传工程；培养基（微生物学的试验介质入C12Q1/00）。
C12N15/00	突变或遗传工程；遗传工程涉及的DNA或RNA，载体（如质粒）或其分离、制备或纯化；所使用的宿主（突变体或遗传工程制备的微生物本身入C12N1/00、C12N5/00、C12N7/00；新的植物入A01H；用组织培养技术再生植物入A01H4/00；新的动物入A01K67/00；含有插入活体细胞的遗传物质以治疗遗传疾病的药剂的应用，基因疗法入A61K48/00，一般肽入C07K）
C12N15/09	.DNA重组技术
C12N15/63	..使用载体引入外来遗传物质；载体；其宿主的使用；表达的调节
C12N15/79	...专门适用于真核细胞宿主的载体或表达系统
C12N15/85	....用于动物细胞