Invention Grant
- Patent Title: Myelin oligodendrocyte glycoprotein, myelin basic protein, and proteolipid protein compositions and methods of use
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Application No.: US15556738Application Date: 2016-03-09
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Publication No.: US10759838B2Publication Date: 2020-09-01
- Inventor: Michael J. Lenardo , Jian Li , Lixin Zheng , Jae W. Lee , Wei Lu
- Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- Applicant Address: US MD Rockville
- Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
- Current Assignee Address: US MD Rockville
- Agency: Locke Lord LLP
- Agent Nicholas J. DiCeglie, Jr.
- International Application: PCT/US2016/021571 WO 20160309
- International Announcement: WO2016/145086 WO 20160915
- Main IPC: C07K14/47
- IPC: C07K14/47 ; A61K38/17 ; A61P25/28 ; A61K38/13
Abstract:
Disclosed is a protein comprising no more than three human autoantigenic proteins, wherein a first human autoantigenic protein comprises a truncated myelin oligodendrocyte glycoprotein (MOG) amino acid sequence, a second human autoantigenic protein comprises a myelin basic protein (MBP) amino acid sequence, and a third human autoantigenic protein comprises a truncated proteolipid protein (PLP) amino acid sequence. Also disclosed are related nucleic acids, pharmaceutical compositions, methods of treating a demyelinating disease, and methods of producing the proteins.
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