Invention Grant
- Patent Title: Brain-targeting prodrug for AMPA receptor synergist, and pharmaceutical applications thereof
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Application No.: US16093754Application Date: 2017-04-11
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Publication No.: US10759822B2Publication Date: 2020-09-01
- Inventor: Song Li , Xinbo Zhou , Dian Xiao , Wu Zhong , Junhai Xiao , Zhibing Zheng , Xingzhou Li , Yunde Xie , Xiaokui Wang
- Applicant: Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
- Applicant Address: CN Beijing
- Assignee: Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
- Current Assignee: Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
- Current Assignee Address: CN Beijing
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@466503c8
- International Application: PCT/CN2017/080083 WO 20170411
- International Announcement: WO2017/177896 WO 20171019
- Main IPC: C07H13/04
- IPC: C07H13/04 ; C07D413/12 ; C07D271/12 ; A61P11/00 ; A61P25/28 ; C07H1/00 ; A61K31/7056 ; A61K31/4245

Abstract:
Disclosed in the present invention is a compound of Formula (I), a geometric or optical isomer, a pharmaceutically acceptable salt, a solvate or a polymorph thereof. Also disclosed in the present invention is a composition comprising the compound of Formula (I), the geometric or optical isomer, the pharmaceutically acceptable salt, the solvate or the polymorph thereof. Also disclosed in the present invention is a use of the compound of Formula (I), the geometric or optical isomer, the pharmaceutically acceptable salt, the solvate or the polymorph thereof in the treatment of a disease or disorder such as a hypoglutamatergic condition, a neurodegenerative disease or respiratory depression, particularly in the treatment of a disease or disorder associated with AMPA receptor.
Public/Granted literature
- US20190077821A1 Brain-Targeting Prodrug for AMPA Receptor Synergist, and Pharmaceutical Applications Thereof Public/Granted day:2019-03-14
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