A machine for automatically manufacturing customized packaging items (I) from continuous laminar material, comprising at least one cutting and creasing unit (2) to form sheets (F) of laminar material with a plurality of cuttings and/or bendinglines (C), at least one variable-geometry forming unit (5) for forming the sheet (F) so cut and creased into a package (I) of predetermined dimensions, a multifunctional robotized manipulator (24) for automatically picking up one sheet (F) at a time from the cutting and creasing unit (2) and feeding the forming unit (5), the manipulator (24) being designed to automatically adapt to the predetermined dimensions of the packaging (I) on the forming unit (5) and interact therewith to form the packaging (I).