A multi-group call setup method and device are disclosed. The method includes determining, by a first MCPTT server, to set up a multi-group call involving N MCPTT groups, where N is an integer greater than or equal to 2, and sending, by the first MCPTT server, a call message to first UE, where the call message is used to add the first UE to the multi-group call, where a first MCPTT user is an associated user of the first UE, and where the first MCPTT user is an MCPTT user in the N MCPTT groups.