Disclosed are method and apparatus for enabling multiple access in a wireless communication system that can enable ultralow latency, ultra-reliable, and high throughput services. The disclosed multiple access method includes: allocating resources for a plurality of user terminals according to space and frequency; performing a discrete Fourier transform on a transmission symbol for each unit of the space, the transmission symbol composed of a plurality of sub-symbols and configured to be transmitted according to the allocated space and frequency resources; and applying a frequency filter and a spatial filter on the Fourier transformation result, and wherein the applying of the frequency filter and the spatial filter comprises: selecting a pulse shaping filter according to an arranged position of the allocated frequency resource for each unit of the space and applying the selected pulse shaping filter on a sample representing a result of applying a Fourier transform on the sub-symbol to a frequency domain.