Transmit diversity schemes may be used for sending sequence-based signals over multiple antennas. For example, a user equipment (UE) may determine an uplink sequence to be transmitted to a base station using multiple antennas. The UE may utilize a transmit diversity scheme for the multiple-antenna transmission of the uplink sequence, where the transmit diversity scheme utilized may be based on a number of symbol periods during which the sequence is transmitted. In accordance with the transmit diversity scheme, the UE may use multiple transmit antennas to transmit different sequences from respective antennas. In other examples, the UE may transmit the uplink sequence using different time or frequency resources. Additionally, the UE may use some combination of different transmit diversity schemes for sequence-based signals. In some aspects, the base station may provide an indication of the transmit diversity scheme that the UE is to use for transmitting the uplink sequence.